Slippery liquid-infused porous surface (SLIPS) is received widespread attention in the anti-fouling field because of its dynamic slippery surface, but the limited effect of physical “anti-adherence” and the problem of lubricant loss restrict its application for practical marine anti-fouling. Inspired by the self-defensive function of P. pavoninus’s poisonous mucus, a SLIPS based on the reversible chemical bonds and the antibacterial effect of coumarin (CmSLIPS) is prepared, which addresses these disadvantages by responsively adaptive lubricity and durability. The CmSLIPS enables the “locking” and “unlocking” mode between lubricant and matrix via the reversible photodimerization of coumarin. It regulates the surface lubricity to adapt to the anti-fouling demand. The reversible chemical bonds of lubricant and matrix reduce lubricant loss and enhance the lubricant stability and anti-fouling durability.